原著論文
1. Enkai S, Kouguchi H, Inaoka DK, Shiba T, Yagi K, Saimoto H, Kita K. (2023) Killing two birds with one stone: discovery of dual inhibitors of oxygen and fumarate respiration in zoonotic parasite, Echinococcus multilocularis. Antimicrobial agents and chemotherapy, 67 (3), aac.01428-22.
2. Kabongo AT, Acharjee R, Sakura T, Bundutidi GM, Hartuti ED, Davies C, Gundogdu O, Kita K, Shiba T*, Inaoka DK* (2023) Biochemical characterization and identification of ferulenol and embelin as potent inhibitors of malate:quinone oxidoreductase from Campylobacter jejuni. Frontiers in Molecular Biosciences, 10, 1095026, *Corresponding authors
3. Nurkanto A, Imamura R, Rahmawati Y, Prabandari EE, Waluyo D, Annoura T, Yamamoto K, Sekijima M, Nishimura Y, Okabe T, Shiba T, Shibata N, Kojima H, Duffy J, Nozaki T. (2022) Dephospho coenzyme A kinase is the exploitable drug target against Plasmodium falciparum: identification of selective inhibitors by high-throughput screening of large chemical compound library. Antimicrobial agents and chemotherapy, 66, e0042022
4. Okawa A, Handa H, Yasuda E, Murota M, Kudo D, Tamura T, Shiba T, Inagaki K. (2022) Characterization and application of L-methionine γ-lyase Q349S mutant enzyme with an enhanced activity toward L-homocysteine. J. biosci. Bioeng. 133, 213-221
5. Cisneros D, Cueto-Díaz EJ, Medina-Gil T, Chevillard R, Bernal-Fraile T, Lopez Sastre R, Aldfer MM, Ungogo MA, Elati HAA, Arai N, Otani M, Matsushiro S, Kojima C, Ebiloma GU, Shiba T,de Koning HP, Dardonville C. (2022) Imidazoline- and benzamidine-based trypanosome alternative oxi-dase inhibitors: synthesis and SAR studies. ACS Med. Chem. Lett., 13, 312–318
6. Hartuti ED, Sakura T, Tagod MSO, Yoshida E, Wang X, Mochizuki K, Acharjee R, Matsuo Y, Tokumasu F, Mori M, Waluyo D, Shiomi K, Nozaki T, Hamano S, Shiba T, Kita K and Inaoka DK (2021) Identification of 3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazine-6-imine derivatives as novel selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Int. J. Mol. Sci., 22, 7236
7. Cueto-Díaz EJ, Ebiloma GU, Alfayez IA, Ungogo MA, Lemgruber L, González-García MC, Giron MD, Salto R, Fueyo-González FJ, Shiba González-Vera JA, Ruedas Rama MA, Orte A, de Koning HP, Dardonville C. (2021) Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent Inhibitors of the Trypanosome Alternative Oxidase. Eur. J. Med. Chem, 220, 113470.
8. Okawa A, Shiba T*, Hayashi M, Onoue Y, Murota M, Sato D, Inagaki J, Tamura T, Harada S, Inagaki K*. (2021) Structural basis for substrate specificity of L-methionine decarboxylase. Protein Science, 30(3), 663-677, doi: 10.1002/pro.4027. *Corresponding authors
9. Yamasaki S, Shoji M, Kayanuma M, Sladek MV, Inaoka DK, Matsuo Y, Shiba T, Young L, Moore AL, Kita K and Shigeta Y. (2021) Weak O2 binding and strong H2O2 binding at the non-heme diiron center of Trypanosome Alternative Oxidase. BBA - Bioenergetics, 1862, 148356, DOI: 10.1016/j.bbabio.2020.148356.
10. Sato D, Hartuti ED, Inaoka DK*, Sakura T, Amalia E, Nagahama M, Yoshioka Y, Tsuji N, Nozaki T, Kita K, Harada S, Matsubayashi M, Shiba T.* (2020) Structural and biochemical features of Eimeria tenella dihydroorotate dehydrogenase, a potential drug target. Genes, 11(12), 1468, doi:10.3390/genes11121468. *Corresponding authors
11. Mochizuki K, Inaoka DK*, Mazet M, Shiba T*, Fukuda K, Kurasawa H, Millerioux Y, Boshart M, Balogun EO, Harada S, Hirayama K, Bringaud F, Kita K. (2020) The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei. BBA - Bioenergetics, 1861, 148283, doi: 10.1016/j.bbabio.2020.148283. *Corresponding authors
12. Uno S, Masuya T, Shinzawa-Itoh K, Lasham J, Haapanen O, Shiba T, Inaoka DK, Sharma V, Murai M, Miyoshi H. (2020) Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I. J. Biol. Chem., 295(8), 2449-2463, doi: 10.1074/jbc.RA119.012347.
13. Balogun EO*, Inaoka DK*, Shiba T*, Tsuge C, May B, Sato T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PAM, Watanabe YI, Moore AL, Harada S, Kita K. (2019) Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei. FASEB J. 33(11), 13002-13013, doi: 10.1096/fj.201901342R. *These authors are equally contributed to this work.
14. Wang X, Miyazaki Y, Inaoka DK, Hartuti ED, Watanabe Y, Shiba T, Harada S, Saimoto H, Burrows JN, Francisco Javier Gamo Benito, Nozaki T, Kiyoshi Kita (2019) Identification of Plasmodium falciparum mitochondrial malate:quinone oxidoreductase inhibitors from the Pathogen Box. Genes, 10(6), 471; https://doi.org/10.3390/genes10060471
15. Shiba T*, Inaoka DK*, Takahashi G, Tsuge C, Kido Y, Young L, Ueda S, Balogun EO, Nara T, Honma T, Tanaka A, Inoue M, Saimoto H, Harada S, Moore AL, Kita K. (2019) Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase. BBA - Bioenergetics, 1860, 375-382. *These authors are equally contributed to this work.
16. Matsubayashi M, Inaoka DK, Komatsuya K, Hatta T, Kawahara F, Sakamoto K, Hikosaka K, Yamagishi J, Sasai K, Shiba T, Harada S, Tsuji N, Kita K. (2019) Novel Characteristics of Mitochondrial Electron Transport Chain from Eimeria tenella. Genes, 10, 29, doi:10.3390/genes10010029.
17. Miyazaki Y*, Inaoka DK*, Shiba T*, Saimoto H, Sakura T, Amallia E, Kido Y, Sakai C, Nakamura M, Moore AL, Harada S, Kita K. Selective cytotoxicity of dihydroorotate dehydrogenase inhibitors to human cancer cells under hypoxia and nutrient-deprived conditions. (2018) Front. Pharmacol., 04 September 2018, doi.org/10.3389/fphar.2018.00997. *These authors are equally contributed to this work.
18. Meco-Navas A, Ebiloma GU, Martín-Domínguez A, Martínez-Benayas AI, Cueto-Díaz EJ, Alhejely AS, Balogun EO, Saito M, Matsui M, Arai N, Shiba T, Harada S, de Koning HP, Dardonville C. (2018) SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase. ACS Med. Chem. Lett., 9, 293-298.
19. Ebiloma GU, Ayuga TD, Gil LA, Balogun EO, Donachie A, Inaoka DK, Shiba T, Harada S, Kita K, de Koning HP, Dardonville C. (2018) Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion. Eur. J. Med. Chem., 150, 385-402.
20. Yamasita T*, Inaoka DK*, Shiba T*, Oohashi T, Iwata S, Yagii T, Kosaka H, Miyoshi H, Harada S, Kita K, Hirano K. (2018) Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors. Scientific Reports, 8 Article number: 2427. *These authors are equally contributed to this work.
21. Hartuti ED, Inaoka DK, Komatsuya K, Miyazaki Y, Miller RJ, Wang X,, Sadikin M, Prabandari EE, Waluyo D, Kuroda M, Amalia E, Matsuo Y, Nugroho NB, Saimoto H, Pramisandi A, Watanabe YI, Mori M, Shiomi K, Balogun EO, Shiba T, Harada S, Nozaki T, Kita K. (2018) Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target. BBA - Bioenergetics, 1859, 191-200.
22. Balogun EO, Inaoka DK, Shiba T, Tokuoka SM, Tokumasu F, Sakamoto K, Kido Y, Michels PAM, Watanabe Y, Harada S, Kita K. (2017) Glycerol Kinase of African Human Trypanosomes Possesses an Intrinsic Phosphatase Activity. BBA - General Subjects, 1861, 2830-2842.
23. Wang X, Inaoka DK, Shiba T, Balogun EO, Allmann S, Watanabe Y, Boshart M, Kita K, Harada S. (2017) Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei. Protein Expression and Purification, 138, 56-62.
24. Sato D, Shiba T, Karaki T, Yamagata W, Nakazawa T, Nozaki T, Harada S. (2017) X-ray snapshots of a pyridoxal enzyme: a catalytic mechanism involving concerted [1,5]-hydrogen sigmatropy in methionine γ-lyase. Scientific Reports, 7, Article number: 4874.
25. Sato D, Shiba T, Yunoto S, Furutani K, Fukumoto M, Kudou D, Tamura T, Inagaki K, Harada S. (2017) Structural and mechanistic insights into homocysteine degradation by a mutant of methionine γ-lyase based on substrate-assisted catalysis. Protein Science, 26, 1224-1230.
26. Sato D, Shiba T, Mizuno S, Kawamura A, Hanada S, Yamada T, Shinozaki M, Yanagitani M, Tamura T, Inagaki K, Harada S. (2017) The hyperthermophilic cystathionine g-synthase from the aerobic crenarchaeon Sulfolobus tokodaii: expression, purification, crystallization and structural insights. Acta Cryst., F 73, 152-158.
27. González FJF, Ebiloma GU, García CI, Bruggeman V, Villamañán JMS, Donachie A, Balogun EO, Inaoka DK, Shiba T, Harada S, Kita K, de Koning HP, Dardonville C. (2017) Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Anti-parasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion. J. Med. Chem., 60, 1509-1522.
28. Inaoka DK, Iida M, Tabuchi T, Honma T, Lee N, Hashimoto S, Matsuoka S, Kuranaga T, Sato K, Shiba T, Sakamoto K, Balogun EO, Suzuki S, Nara T, da Rocha JR, Montanari CA, Tanaka A, Inoue M, Harada S, Kita K. (2016) Open form inducer: a new approach for structure-based drug design. PLoS One, 11(11), e0167078.
29. Young L, May B, Shiba T, Harada S, Inaoka DK, Kita K, Moore AL. (2016) Structure and Mechanism of Action of the Alternative Quinol Oxidases. Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling Volume 41 of the series Advances in Photosynthesis and Respiration pp 375-394.
30. Inaoka DK, Shiba T, Sato D, Balogun EO, Sasaki T, Nagahama M, Oda M, Matsuoka S, Ohmori J, Honma T, Inoue M, Kita K, Harada S. (2015) Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria. Int. J. Mol. Sci., 16(7), 15287-15308.
31. Yoshino R, Yasuo N, Inaoka DK, Hagiwara Y, Ohno K, Orita M, Inoue M, Shiba T, Harada S, Honma T, Balogun EO, da Rocha JR, Montanari CA, Kita K, Sekijima M. (2015) Pharmacophore Modeling for Anti-Chagas Drug Design Using the Fragment Molecular Orbital Method. PLoS One, 10(5), e0125829.
32. Balogun EO, Inaoka DK, Shiba T, Kido Y, Tsuge C, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Kita K, Harada S. (2014) Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase. Mol Microbiol., 94, 1315-1329.
33. Young L, May B, Pendlebury-Watt A, Shearman J, Elliott C, Albury MS, Shiba T, Inaoka DK, Harada S, Kita K, Moore AL. (2014) Probing the ubiquinol-binding site of recombinant Sauromatum guttatum alternative oxidase expressed in E. coli membranes through site-directed mutagenesis. Biochimica et Biophysica Acta, 1837, 1219-1225.
34. Balogun EO, Balogun JAB, Yusuf S, Inuwa HM, Ndams IS, Sheridan P, Inaoka DK, Shiba T, Harada S, Kita K, Esievo KAN, Nok AJ. (2014) Anemia amelioration by lactose infusion during trypanosomosis could be associated with erythrocytes membrane de-galactosylation. Veterinary Parasitology, 199, 259-263.
35. Young L, Shiba T, Harada S, Kita K, Albury MS, Moore AL. (2013) The alternative oxidases: simple oxidoreductase proteins with complex functions. Biochem Soc Trans. 41, 1305-1311.
36. Balogun EO, Inaoka DK, Shiba T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Harada S, Kita K. (2013) Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target. J. Biochemistry, 154, 77-84.
37. Moore AL, Shiba T, Young L, Harada S, Kita K, Ito K. (2013) Unraveling the heater: new insights into the structure of the alternative oxidase. Annu. Rev. Plant Biol., 64, 637-663.
38. Shiba T, Kido Y, Sakamoto K, Inaoka DK, Tsuge C, Tatsumi R, Takahashi G, Balogun EO, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Saimoto H, Moore AL, Harada S, Kita K. (2013) Structure of the trypanosome cyanide-insensitive alternative oxidase. Proc. Natl. Acad. Sci. USA, 110, 4580-4585.
39. Natala AJ, Balogun EO, Balogun JA, Inuwa HM, Nok AJ, Shiba T, Harada S, Kita K, Agbede RI, Esievo KA. (2013) Identification and characterization of sialidase-like activity in the developmental stages of Amblyomma variegatum. J. of Med. Entomol., 50, 85-93.
40. Narikawa R, Ishizuka T, Muraki N, Shiba T, Kurisu G, Ikeuchi M. (2013) Structures of cyanobacteriochromes from phototaxis regulators AnPixJ and TePixJ reveal general and specific photoconversion mechanism. Proc. Natl. Acad. Sci. USA, 110, 918-923.
41. Fukumoto M, Kudou D, Murano S, Shiba T, Sato D, Tamura T, Harada S, Inagaki K. (2012) The role of amino acid residues in the active site of L-methionine γ-lyase from Pseudomonas putida. Biosci. Biotechnol. Biochem., 76, 1275–1284.
42. Shimizu H, Osanai A, Sakamoto K, Inaoka DK, Shiba T, Harada S, Kita K. (2012) Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum. J. Biochemistry, 151, 589–592.
43. Okuda M, Shiba T, Inaoka DK, Kita K, Kurisu G, Mineki S, Harada S, Watanabe Y, Yoshinari S. (2011) A conserved lysine residue in the crenarchaea-specific loop is important for the crenarchaeal splicing endonuclease activity. J. Mol. Biol., 405, 92-104.
44. Matoba K, Shiba T, Takeuchi T, Sibley LD, Seiki M, Kikyo F, Horiuchi T, Asai T, Harada S. (2010) Crystallization and preliminary X-ray structural analysis of nucleoside triphosphate hydrolases from Neospora caninum and Toxoplasma gondii. Acta Cryst. F 66, 1445-1448.
45. Muraki N, Seo D, Shiba T, Sakurai T, Kurisu G. (2010) Asymmetric dimeric structure of ferredoxin-NAD(P)+ oxidoreductase from the green sulfur bacterium Chlorobaculum tepidum: implications for binding ferredoxin and NADP+. J. Mol. Biol., 401, 403-414.
46. Muraki N, Nomata J, Ebata K, Mizoguchi T, Shiba T, Tamiaki H, Kurisu G, Fujita Y. (2010) X-ray crystal structure of the light-independent protochlorophyllide reductase. Nature, 465, 110-115.
47. Balogun EO, Inaoka DK, Kido Y, Shiba T, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Harada S, Kita K. (2010) Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase. Acta Cryst. F 66, 304-308.
48. Kido Y, Shiba T, Inaoka DK, Sakamoto K, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Moore A, Harada S, Kita K. (2010) Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei. Acta Cryst. F 66, 275-278.
49. Yoshinari S, Shiba T, Inaoka DK, Itoh T, Kurisu G, Harada S, Kita K, Watanabe Y. (2009) Functional importance of crenarchaea-specific extra-loop revealed by an X-ray structure of a heterotetrameric crenarchaeal splicing endonuclease. Nucleic. Acids Res., 37, 4787-4798.
50. Narikawa R, Muraki N, Shiba T, Ikeuchi M, Kurisu G. Crystallization and preliminary X-ray studies of the chromophore-binding domain of cyanobacteriochrome AnPixJ from Anabaena sp. PCC 7120. Acta Cryst. F 65, 159-162.
51. Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S. (2008) Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. Biochemistry, 47, 10881-10891.
52. Muraki N, Seo D, Shiba T, Sakurai T, Kurisu G. (2008) Crystallization and preliminary X-ray studies of ferredoxin-NAD(P)+ reductase from Chlorobium tepidum. Acta Cryst. F 64, 186-189.
53. Inoue M, Shiba T, Ihara K, Yamada Y, Hirano S, Kamikubo H, Kataoka M, Kawasaki M, Kato R, Nakayama K, Wakatsuki S. (2007) Molecular basis for autoregulatory interaction between GAE domain and hinge region of GGA1. Traffic, 8, 904-913.
54. Shiba T, Koga H, Shin HW, Kawasaki M, Kato R, Nakayama K, Wakatsuki S. (2006) Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. Proc. Natl. Acad. Sci. USA, 103, 15416-15421.
55. Shiba T, Kakuda S, Ishiguro M, Morita I, Oka S, Kawasaki T, Wakatsuki S, Kato R. (2006) Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope. Proteins, 65, 499-508.
56. Kubota T, Shiba T, Sugioka S, Furukawa S, Sawaki H, Kato R, Wakatsuki S, Narimatsu H. (2006) Structural basis of carbohydrate transfer activity by human UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase (pp-GalNAc-T10). J. Mol. Biol., 359, 708-727.
57. Akutsu M, Kawasaki M, Katoh Y, Shiba T, Yamaguchi Y, Kato R, Kato K, Nakayama K, Wakatsuki S. (2005) Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain. FEBS letters, 579, 5385-5391.
58. Kawasaki M, Shiba T, Shiba Y, Yamaguchi Y, Matsugaki N, Igarashi N, Suzuki M, Kato R, Kato K, Nakayama K, Wakatsuki S. (2005) Molecular mechanism of ubiquitin recognition by GGA3 GAT domain. Genes to Cells, 10, 639-654.
59. Yamada Y, Inoue M, Shiba T, Kawasaki M, Kato R, Nakayama K, Wakatsuki S. (2005) Structure determination of GGA-GAE and gamma1-ear in complex with peptides: crystallization of low-affinity complexes in membrane traffic. Acta Cryst. D 61, 731-736.
60. Shiba T, Kametaka S, Kawasaki M, Shibata M, Waguri S, Uchiyama Y, Wakatsuki S. (2004) Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1. Traffic, 5, 437-448.
61. Kakuda S*, Shiba T*, Ishiguro M, Tagawa H, Oka S, Kajihara Y, Kawasaki T, Wakatsuki S, Kato R. (2004) Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1. J. Biol. Chem., 279, 22693–22703. *: These authors contributed equally to this work.
62. Shiba Y, Katoh Y, Shiba T, Yoshino K, Takatsu H, Kobayashi H, Shin HW, Wakatsuki S, Nakayama K. (2004) GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination. J. Biol. Chem., 279, 7105–7111.
63. Shiba T, Kawasaki M, Takatsu H, Nogi T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Nakayama K, Wakatsuki S. (2003) Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport. Nature Struct. Biol., 10, 386-393.
64. Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S. (2002) Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain. Nature Struct. Biol., 9, 527-531.
65. Shiba T, Takatsu H, Nogi T, Matsugaki N, Kawasaki M, Igarashi N, Suzuki M, Kato R, Earnest T, Nakayama K, Wakatsuki S. (2002) Structural basis for recognition of acidic-cluster dileucine sequence by GGA1. Nature, 415, 937-941.
66. Shiba T, Harada S, Sugawara H, Naitow H, Kai K, Satow Y. (2000) Crystallization and preliminary X-ray analysis of a bacterial lysozyme produced by Streptomyces globisporus. Acta Cryst. D 56, 1462-1463.
67. Matsumura H, Shiba T, Inoue T, Harada S, Kai Y. (1998) A novel mode of target recognition suggested by the
2.0Å structure of holo S100B from bovine brain. Structure, 6, 233-241.
総説、書籍
1. 大川敦司, 志波智生, 林 将也, 尾上友基, 室田昌輝, 佐藤 暖, 稲垣純子, 田村 隆, 原田繁春, 稲垣賢二 (2021) L-メチオニン脱炭酸酵素のX線結晶構造と基質特異性の構造的基盤. ビタミン Vol. 95(7), 331-335.
2. 佐藤 暖，志波智生，湯之戸俊介，古谷和大，福本充樹， 工藤大蔵，田村 隆，稲垣賢二，原田繁春 (2017) メチオニン γ-リアーゼ C116H 変異体は基質支援触媒作用によって ホモシステインを分解する. ビタミン Vol. 92(3), 117-120 (2017)
3. 北潔, 志波智生, 稲岡ダニエル健, 原田繁春 (2014) 生命科学から創薬へのイノベーション 第7章 南山堂.
4. 北潔, 志波智生, 斎本博之, 稲岡ダニエル健, 原田繁春 (2014) 微生物からの贈り物アスコフラノン-アフリカ睡眠病からがん細胞まで- MEDCHEM NEWS, Vol. 24-No.4, 44-50.
5. 北潔, 志波智生, 原田繁春 (2014) 希少疾病のアカデミア創薬 –グローバルオーファンドラッグ創成をめざして– 実験医学増刊, Vol. 32-No. 2, 210-215.
6. 志波智生, 高橋元, 原田繁春, 斎本博之, 城戸康年, 稲岡ダニエル健, 北潔 (2013) アフリカ睡眠病治療薬の候補化合物と標的タンパク質との複合体構造. 日本結晶学会誌, 55, 254-259.
7. 志波智生 (2008) 結晶化条件の最適化. 蛋白質科学会アーカイブ 1, e033
8. 志波智生 (2008) 結晶化条件のスクリーニング. 蛋白質科学会アーカイブ 1, e023
9. 志波智生、古賀裕士、申恵媛、川崎政人、加藤龍一、中山和久、若槻壮市(2007) FIP3による低分子量GTPase Rab11の認識機構の研究. 日本結晶学会誌, 49, 231-237.
10. 志波智生 (2006) 細胞内小胞輸送およびタンパク質の翻訳後修飾のX線結晶構造解析による研究. 日本結晶学会誌, 48, 207-215.
11. 志波智生、角田品子、岡昌吾、石黒正路、川嵜敏祐、若槻壮市、加藤龍一 (2005) HNK-1糖鎖の生合成に必須な糖転移酵素GlcAT-Pのユニークな糖鎖基質認識機構. 生化学, 77, 153-158.
12. 志波智生、川崎政人、高津宏之、禾晃和、松垣直宏、五十嵐教之、鈴木守、加藤龍一、中山和久、若槻壮市 (2003) リソソームタンパク質の輸送におけるARFによるGGAタンパク質の膜へのリクルートの分子機構. PHOTON FACTORY NEWS, 21-2, 29-35
13. 禾晃和、芝陽子、川崎政人、志波智生、松垣直宏、五十嵐教之、鈴木守、加藤龍一、高津宏之、中山和久、若槻壮市 (2002) アダプチンearドメインの立体構造に基づいた小胞輸送制御機構の解析. PHOTON FACTORY NEWS, 20-2, 24-28.
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